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August
HIFU — How Long to See Results on the Face?
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As skin ages, it gradually loses the three structural proteins that define its youthfulness: collagen, elastin, and hyaluronic acid.
The result is skin that feels thinner, looks less firm, and loses the density and bounce it once had. mesohyal® redenx by mesoestetic is a clinically advanced intradermal injectable that goes beyond surface-level hydration — it delivers biomimetic peptides directly into the dermis to actively stimulate the production of collagen and other structural proteins, reversing the biological processes behind skin ageing at their source. At Estelaza Clinic in Dubai Silicon Oasis, we offer mesohyal® redenx as part of our evidence-based approach to skin regeneration, revitalisation, and long-term firmness.


mesohyal® redenx is an intradermal medical solution developed by mesoestetic® — one of the world's leading medical aesthetic laboratories.
It belongs to the mesohyal® range: a family of CE-marked, sterile injectable devices formulated on a free hyaluronic acid base, enriched with biomolecules of proven clinical efficacy.
What sets mesohyal® redenx apart from standard skin boosters is its specific focus on collagen induction and structural protein synthesis through biomimetic peptides — molecules designed to mimic the body’s own signalling proteins and instruct the skin to rebuild itself from within.
The product carries CE Medical Marking, confirming its safety, biocompatibility, and proven efficacy as a medical device.
The hyaluronic acid base of mesohyal® redenx is free (non-crosslinked), meaning it integrates naturally into the skin's intercellular matrix. It increases water retention in the dermis, boosts hydration immediately, and creates the optimal environment for peptide activity.
A powerful biomimetic peptide that mimics the action of TSP-1 (thrombospondin-1), a protein that activates TGF-β — the key growth factor responsible for collagen synthesis. This is particularly important for women in the peri- and post-menopausal stages: declining oestrogen levels reduce TGF-β, accelerating the loss of collagen and elastin. Palmitoyl tripeptide-5 restores this signalling pathway, activating collagen I, III, elastin, and fibronectin synthesis, while simultaneously inhibiting the MMPs (matrix metalloproteinases) that break down the skin's structural matrix. In vitro evidence: +116% increase in collagen synthesis in fibroblast culture after 24 hours.
This peptide drives the synthesis of lumican — a proteoglycan that is naturally lost with ageing and is essential for the proper joining and organisation of collagen fibres. When lumican levels are restored, collagen fibres align correctly, giving the skin measurably improved elasticity, resistance, and structural integrity. Clinical evidence: 97% of subjects showed visible signs of improvement at the end of treatment; 100% noticed improvement from the very first session.
The formula transforms macrophages into their anti-inflammatory phenotype and regulates cytokine expression (IL-10, IL-4, TGF-β), calming chronic low-grade inflammation — a key driver of skin aging in urban dwellers.
mesohyal® redenx is designed to restructure, firm, and redensify the skin. It is specifically indicated for:
It is also an excellent preventive and maintenance treatment for younger patients who want to stay ahead of the ageing process, and is highly compatible with other procedures — including dermal fillers, botulinum toxin, laser, peels, and radiofrequency — to enhance and extend their results.

mesohyal® redenx is designed to restructure, firm, and redensify the skin. It is specifically indicated for:
mesoestetic® designed mesohyal® redenx as a cell regenerator — distinct from traditional collagen inducers (such as CaHa, PLLA, or PCL) that work through a controlled inflammatory response. Instead, mesohyal® redenx triggers a non-inflammatory regenerative response that selectively acts on multiple cellular processes simultaneously: collagen synthesis, MMP inhibition, extracellular matrix restructuring, and hydration — all without the inflammation or downtime associated with biostimulators.
This makes it one of the most biocompatible options in the biostimulation market, with very high tolerability and no recorded side effects beyond mild, transient redness lasting up to 3 days in clinical studies.
mesohyal® redenx can be used across multiple areas of the face and body:
3 sessions, spaced 1 month apart.
After completing the initial course, periodic maintenance sessions are recommended — your doctor will advise on timing based on your skin's response and personal goals.
Our doctors perform mesohyal® redenx using one or a combination of three intradermal injection techniques, selected based on the treatment area and the patient's skin condition: • Point by point — precise deposits for targeted redensification • Intradermal papule — for uniform distribution across larger areas • Tracing / linear threading — for wrinkle correction along lines and folds
Side effects are minimal and transient. In clinical evaluations, no adverse effects were recorded beyond 3 days. Most patients resume their normal activities immediately or the following day.

CE-marked medical device — not a cosmetic; a clinically validated intradermal solution held to the highest European medical device standards.
Biomimetic precision — the peptides mimic the body’s own proteins, producing natural-feeling, natural-looking improvement.
Dual action — stimulates new collagen while protecting existing collagen from degradation.
Non-inflammatory — unlike biostimulators, no controlled injury is needed; the regeneration is direct and selective.
Proven results from session one — 100% of patients in clinical studies noticed improvement after their very first treatment.
Compatible with all other aesthetic treatments — enhances and prolongs the effects of fillers, toxin, laser, and energy-based devices.
Broad treatment area coverage — face, neck, neckline, décolleté, and hands.
mesohyal® redenx is a CE-marked intradermal injectable by mesoestetic® that combines free hyaluronic acid (15 mg/ml) with two biomimetic peptides — Palmitoyl tripeptide-5 and Acetyl tetrapeptide-9 — to stimulate collagen synthesis, rebuild the extracellular matrix, and firm and redensify ageing skin.
Fillers add volume by physically filling a space. mesohyal® redenx does not add volume — it triggers the skin’s own biological processes to produce more collagen and structural proteins, improving skin quality, firmness, and density from within.
? It belongs to the biostimulation category but works through a different mechanism. Traditional biostimulators (CaHa, PLLA) trigger collagen through a controlled inflammatory response. mesohyal® redenx uses biomimetic peptides for a non-inflammatory, highly selective cellular regeneration response — making it more comfortable, better tolerated, and compatible with a wider range of patients.
The standard protocol is 3 sessions spaced 1 month apart. Maintenance sessions are then recommended periodically to preserve results.
Clinical data shows that 100% of patients noticed improvement from their very first session. More significant structural improvement — firmer, denser, more elastic skin — develops progressively over the course of the 3-session protocol as new collagen forms.
Yes — mesohyal® redenx is specifically designed to address the type of skin ageing associated with declining oestrogen levels in peri- and post-menopausal women: fragile, dehydrated, sagging skin that has lost density and structural support. The Palmitoyl tripeptide-5 ingredient directly targets the TGF-β pathway that oestrogen normally activates.
Yes. It is fully compatible with dermal fillers, botulinum toxin, laser treatments, chemical peels, and radiofrequency. When used alongside these procedures it enhances and prolongs their results.
Patients who are pregnant or breastfeeding, have active skin infections, inflammation, or autoimmune conditions in the treatment area, or have known hypersensitivity to any component should not undergo this treatment. A full medical consultation at Estelaza Clinic will confirm your suitability.
Ready to restore your skin’s structure, firmness, and radiance? Book a consultation at Estelaza Clinic, Dubai Silicon Oasis and let our doctors design a personalised treatment plan for you.
All treatments are performed by DHA-licensed medical professionals. Individual results vary. This page is for informational purposes only and does not constitute medical advice.
Your experiences mean the world to us! At Estelaza Clinic, we love hearing how our treatments make a positive difference in your life. Every review helps us grow, improve, and keep delivering the care you deserve. Thank you for trusting us on your beauty and wellness journey.
EXCELLENT Based on 248 reviews Posted on Google Ahmad AhmadTrustindex verifies that the original source of the review is Google. مكان جدا رائع وخدمه ممتاز شكرا للكادر الطبي والدكتورة ميرل عنجد شغل يجنن مبسوط كتير با النتيجهPosted on Google Fatima AlsuwaidiTrustindex verifies that the original source of the review is Google. Dr nouf is the best love her honestly and the staff very friendly and helpfulPosted on Google Lara LaraTrustindex verifies that the original source of the review is Google. Lovely stuff and doctor I’m happy with my resultsPosted on Google Kristina MatarTrustindex verifies that the original source of the review is Google. I had fantastic experience in Estelaza clinic. Staff is very professional and welcoming. Dr Nouf has the most gentle hands. She did a magic contouring my face: (chin, cheeks, jaws) and gave super natural volume to my lips. I feel 10 years younger and super glowy and fresh. Can’t wait to be back after the summer. Thank youPosted on Google فاطمة عبيدTrustindex verifies that the original source of the review is Google. كانت تجربتي في العيادة مميزة للغاية، حيث يتميز الطاقم بالرحابة وحسن التعامل، والمواعيد مرنة ومنظمة. كما أن الدكتورة نوف محترفة وهادئة في إجراءاتها التجميلية غير الجراحية. أنصح بشدة بزيارة العيادة، فهي تستحق الثقة والتجربة. 🤍
If you've been searching for laser hair removal prices in…
If you've been searching for laser hair removal prices in…
If you've been searching for laser hair removal prices in…

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